Pyridinium chloride → HCID 20368388, compound

Participants

Reaction Steps

A mixture of 10.9 g. of the product from Example 16 and 33.6 g. of pyridine hydrochloride was refluxed in a 220° C. oil bath for 1.5 hours. The hot reaction mixture then was poured over an ice-water mixture, and the resulting solid was collected. The solid was washed with water and dissolved in ethyl acetate. The ethyl acetate solution was washed with saturated aqueous sodium chloride and dried over magnesium sulfate. The ethyl acetate solution then was filtered and evaporated. The residue was recrystallized from a mixture of methanol and a minimum of acetone to give 5.07 g. (39 percent) of the title compound, m.p. 215° C.

Provenance & Evidence