Diethyl Ether → HCID 20368531, compound

Participants

Reaction Steps

To a suspension of 10 g. of lithium aluminum hydride in 300 ml. of diethyl ether, 18.7 g. of ethyl 2-(3,4-dichlorophenyl)-3-dimethylaminobutyrate is added dropwise with stirring. The mixture is refluxed for 40-45 hours and after cooling with an ice bath, 50 ml. of water is added very slowly. After filtering off and thoroughly washing out the inorganic salts, the dried organic filtrate is evaporated and the residue is distilled in vacuo at 115° C/0.4 mm Hg to yield 13 g. of the title compound. The hydrochloride salt melts at 188°-190° C.

Provenance & Evidence