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Pyclazolam → 8-chloro-1-[2-(diethylamino)ethyl]-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyclazolam | HCID 20368150 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Acetyl chloride | HCID 6367 | — |
| 溶媒 | Tetraethylmethylenediamine | HCID 66020 | — |
| 生成物 | 8-chloro-1-[2-(diethylamino)ethyl]-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine | HCID 20368139 | — |
反応手順
In the manner given in Example 1, a solution of 8-chloro-1-methyl-6-(pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine in dimethylformamide, N,N,N',N'-tetraethyldiaminomethane and acetylchloride (in 0.5 molar excess compared to the N,N,N',N'-tetraethyldiaminomethane) are reacted together to give 8-chloro-1-[2-(diethylamino)ethyl]-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04075221 |
| 出典データセット | uspto-grants-1978_02 |
| ORD ID | ord-8a127ac6ee8e49b79f4ab10240dd2035 |
| 出典メモ | uspto-grants-1978_02 |