HuagongsheHuagongshe Chemistry Print Report · For research reference only
Flubromazolam → 8-bromo-1-[2-(diethylamino)ethyl]-6-(o-fluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Flubromazolam | HCID 21930924 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Acetyl chloride | HCID 6367 | — |
| Solvent | Tetraethylmethylenediamine | HCID 66020 | — |
| Product | 8-bromo-1-[2-(diethylamino)ethyl]-6-(o-fluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine | HCID 20368156 | — |
Reaction Steps
In the manner given in Example 1, a solution of 8-bromo-1-methyl-6-(o-fluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine in dimethylformamide, N,N,N',N'-tetraethyldiaminomethane and acetyl chloride (in 0.5 molar excess compared to the N,N,N',N'-tetraethyldiaminomethane) are reacted together to give 8-bromo-1-[2-(diethylamino)ethyl]-6-(o-fluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04075221 |
| Source dataset | uspto-grants-1978_02 |
| ORD ID | ord-7f53ded15d5045229c78e7ed5c815b6f |
| Source note | uspto-grants-1978_02 |