HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-methylthio-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine → 8-methylthio-1-[2-(diethylamino)ethyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-methylthio-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine | HCID 20368149 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Acetyl bromide | HCID 10482 | — |
| Solvent | Tetraethylmethylenediamine | HCID 66020 | — |
| Product | 8-methylthio-1-[2-(diethylamino)ethyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine | HCID 20368153 | — |
Reaction Steps
In the manner given in Example 1, a solution of 8-methylthio-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine in dimethylformamide, N,N,N',N'-tetraethyldiaminomethane and acetyl bromide (in 0.5 molar excess compared to the N,N,N',N'-tetraethyldiaminomethane) are reacted together to give 8-methylthio-1-[2-(diethylamino)ethyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04075221 |
| Source dataset | uspto-grants-1978_02 |
| ORD ID | ord-c5b6742a322347ed9ff1683dfbbc732c |
| Source note | uspto-grants-1978_02 |