Thionyl Chloride → [(2,2,2-Trifluoroethyl)sulfanyl]acetyl chloride

HRID 616676Notes

Reaction equation

HRID 616676 reaction equation
S(Cl)([Cl:3])=O.[F:5][C:6]([F:14])([F:13])[CH2:7][S:8][CH2:9][C:10](O)=[O:11]>>[F:5][C:6]([F:14])([F:13])[CH2:7][S:8][CH2:9][C:10]([Cl:3])=[O:11]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 167908082-[(2,2,2-Trifluoroethyl)sulfanyl]acetic acid

Product 1

HCID 21816785[(2,2,2-Trifluoroethyl)sulfanyl]acetyl chloride

Procedure

Thionyl chloride (21.9 g, 184 mmol) and trifluoroethylmercaptoacetic acid (15.9 g, 91 mmol) were stirred together overnight. The excess reagent was removed in vacuo and the product was distilled; bp 62°-68°/20 mm.

Workup

  1. customThe excess reagent was removed in vacuo
  2. distillationthe product was distilled

Sources & evidence

ORD record
ord-8eb4f68c6ce7460d976b5ec60ac2aaf0
Source dataset
uspto-grants-1978_02
Patent number
US04075338

Reaction notes

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