反应详情

A solution of 19.35 g of 1-(p-acetamido-phenoxy)-2,3-epoxy-propane and 9.15 g of 1-(4-piperidyl)-2-oxo-hexahydropyrimidine in 10 ml of abs. ethanol is heated to 95° C. The reaction product crystallises out at boiling heat after about 5 minutes. The crystal broth is diluted with 10 ml of abs. ethanol and heated for a further 5 hours. When the reaction is terminated the batch is evaporated in vacuo and the residue is recrystallised from abs. ethanol/ether to yield the 1-[3-(p-acetamido-phenoxy)-2-hydroxypropyl]-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine, which melts at 218°-221° C.

1. customThe reaction product crystallises out
2. temperatureat boiling heat after about 5 minutes
3. additionThe crystal broth is diluted with 10 ml of abs
4. temperatureethanol and heated for a further 5 hours
5. customWhen the reaction is terminated the batch
6. customis evaporated in vacuo
7. customthe residue is recrystallised from abs