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HRID616684

反应详情

EQUATION

反应方程式

HRID 616684 的结构方程式

REACTANTS

反应物

2
结构：Clc1ccccc1OCC1CO1
HCID137500

2-(2-Chlorophenoxymethyl)oxirane

C9H9ClO2

结构：O=C1NCCCN1C1CCNCC1
HCID15572666

1-(Piperidin-4-yl)tetrahydropyrimidin-2(1H)-one

C9H17N3O

PRODUCTS

生成物

1
结构：O=C1NCCCN1C1CCN(CC(O)COc2ccccc2Cl)CC1
HCID20368054

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A solution of 9.2 g of 1-(o-chloro-phenoxy)-2,3-epoxy-propane and 9.15 g of 1-(4-piperidyl)-2-oxo-hexahydro-pyrimidine in 7 ml of abs. ethanol is heated for 5 hours to 95° C and then evaporated in vacuo. The residue is recrystallised from chloroform/petroleum ether to yield the 1-[3-(o-chloro-phenoxy)-2-hydroxypropyl]-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine, which melts at 150°-153° C.

WORKUP

后处理

  1. customevaporated in vacuo
  2. customThe residue is recrystallised from chloroform/petroleum ether