HCID 20300244, compound → 3-(5,6-Dihydro[1,2,4]triazolo[5,1-a]isoquinolin-2-yl)phenol

Participants

Reaction Steps

2-(3-Benzyloxyphenyl)-5,6-dihydro-s-triazolo-[5,1-a]isoquinoline (17.7 g.) is dissolved in 500 ml. of ethanol and hydrogenated at atmospheric pressure and room temperature in the presence of 3 g. of 10% Pd on charcoal. After filtration of the catalyst, the solution is concentrated to 100 ml. The product which precipitates on cooling is purified by crystallization from ethanol. Yield 10.1 g.; m.p. 201°-2° C.

Provenance & Evidence