Ethyl 3-methoxybenzimidate → 8-Methoxy-2-(m-methoxyphenyl)-5,6-dihydro-s-triazolo-[5,1-a]isoquinoline

HRID 616694Notes

Reaction equation

HRID 616694 reaction equation
[NH2:1][N:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:12][CH3:13])[CH:8]=2)[C:3]1=O.C(O[C:18](=[NH:27])[C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[CH:20]=1)C>>[CH3:13][O:12][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[C:3]1=[N:27][C:18]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[CH:20]=3)=[N:1][N:2]1[CH2:11][CH2:10]2

Participants

3

Reactant 2

HCID 12282162Ethyl 3-methoxybenzimidateHCID 124011982-amino-6-methoxy-3,4-dihydro-1(2H)-isoquinolinone

Product 1

HCID 203003028-Methoxy-2-(m-methoxyphenyl)-5,6-dihydro-s-triazolo-[5,1-a]isoquinoline

Procedure

The compound is prepared according to the procedure of Example 1 from 2-amino-6-methoxy-3,4-dihydro-1(2H)-isoquinolinone (prepared according to the procedure described in Belgian Pat. No. 780,885; m.p. 101°-3° C) and m-methoxybenzimidic acid ethyl ester; m.p. 132°-3° C.

Workup

  1. customThe compound is prepared
  2. customprepared

Sources & evidence

ORD record
ord-cea2384b09e446d8a846dc753135e21c
Source dataset
uspto-grants-1978_02
Patent number
US04075341

Reaction notes

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