3-Pyridinemethanamine → HCID 20368869, compound

HRID 616700Notes

Reaction equation

HRID 616700 reaction equation
[SH:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[O:10])=[CH:4][CH:3]=1.[N:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH2:17][NH2:18])[CH:12]=1>C1C=CC=CC=1>[N:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH2:17][NH:18][C:9]([NH:8][C:5]2[CH:6]=[CH:7][C:2]([SH:1])=[CH:3][CH:4]=2)=[O:10])[CH:12]=1

Participants

4

Reactant 2

HCID 310183-PyridinemethanamineHCID 190755954-Isocyanatobenzene-1-thiol

Product 1

HCID 20368869HCID 20368869, compoundYield 77.5%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To 4-mercaptophenyl isocyanate (0.9 g., 0.006 mol) in 50 ml. of anhydrous benzene was added 3-pyridylmethylamine (0.65 g., 0.006 mol). An exothermic reaction caused the temperature to rise to 40° C. and a white precipitate formed. The reaction mixture was momentarily heated to reflux, then cooled to room temperature and filtered to give 1.2 g. melting at 155°-159° C. The product was a 77.5% yield of 1-(3-pyridylmethyl)-3-(4-mercaptophenyl)urea.

Workup

  1. customAn exothermic reaction
  2. customto rise to 40° C.
  3. customa white precipitate formed
  4. temperatureThe reaction mixture was momentarily heated
  5. temperatureto reflux
  6. filtrationfiltered
  7. customto give 1.2 g

Sources & evidence

ORD record
ord-06840479ebaa4750b302436ebfce8d03
Source dataset
uspto-grants-1978_02
Patent number
US04075345

Reaction notes

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