Hydrochloric Acid → HCID 86735493, compound

Participants

Reaction Steps

A mixture of 4-bromo-1-(4-fluoro-2-nitrophenyl)-1,1-ethylenedioxy-n-butane (3.3 g), 4-hydroxy-4-(3-trifluoromethylphenyl)piperidine (1.96 g), potassium carbonate (1.1 g), potassium iodide (20 mg) and methyl isobutyl ketone (25 g) was heated under refluxing for one hour. To the resulting mixture, 13% hydrochloric acid (8.2 g) was added under cooling, and the precipitated crystals were collected by filtration, washed with toluene and dried to give 3.9 g (91.1%) of 4-[4-hydroxy-4-(3-trifluoromethylphenyl)piperidino]-1-(4-fluoro-2-nitrophenyl)-1,1-ethylenedioxy-n-butane hydrochloride. M.P. 229° C (decomp.).

Provenance & Evidence