6-chloro-2-phenyl-1H-indole → 3,5,5-tris(6-chloro-2-phenyl-3-indolyl)-2(5H)-furanone

HRID 616783Notes

Reaction equation

HRID 616783 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:17]([CH2:21][C:22]([C:24]3[C:32]4[C:27](=[CH:28][C:29]([Cl:33])=[CH:30][CH:31]=4)[NH:26][C:25]=3[C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)=[O:23])[C:18](O)=[O:19])=[C:7]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[NH:8]2)=[CH:4][CH:3]=1.[Cl:40][C:41]1[CH:49]=[C:48]2[C:44]([CH:45]=[C:46]([C:50]3[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=3)[NH:47]2)=[CH:43][CH:42]=1>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:17]3[C:18](=[O:19])[O:23][C:22]([C:24]4[C:32]5[C:27](=[CH:28][C:29]([Cl:33])=[CH:30][CH:31]=5)[NH:26][C:25]=4[C:34]4[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=4)([C:45]4[C:44]5[C:48](=[CH:49][C:41]([Cl:40])=[CH:42][CH:43]=5)[NH:47][C:46]=4[C:50]4[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=4)[CH:21]=3)=[C:7]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[NH:8]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 106093646-chloro-2-phenyl-1H-indoleHCID 204427412,4-Bis(6-chloro-2-phenyl-3-indolyl)-4-oxobutanoic acid

Product 1

HCID 204427163,5,5-tris(6-chloro-2-phenyl-3-indolyl)-2(5H)-furanone

Procedure

Following a procedure similar to that described above in part A of this example except that 2,4-bis(6-chloro-2-phenyl-3-indolyl)-4-oxobutanoic acid is used in place of 2,4-bis(1-n-propyl-2-methyl-3-indolyl)-4-oxobutanoic acid and 6-chloro-2-phenylindole is used instead of 1-n-propyl-2-methylindole, there is obtained 3,5,5-tris(6-chloro-2-phenyl-3-indolyl)-2(5H)-furanone (Formula III: R=R2 =H; R1 =R3 =C6H5 ; Y=Y1 =6-Cl).

Sources & evidence

ORD record
ord-73313fab909a47c2a937c40f3b34abe5
Source dataset
uspto-grants-1978_02
Patent number
US04075224

Reaction notes

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