3,5-bis[1-(4-bromobenzyl)-2-isopropyl-3-indolyl]-2(3H)-furanone → 3,5-bis[1-(4-bromobenzyl)-2-isopropyl-3-indolyl]-2(5H)-furanone

HRID 616790Notes

Reaction equation

HRID 616790 reaction equation
[Br:1][C:2]1[CH:46]=[CH:45][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]([CH:16]3[CH:20]=[C:19]([C:21]4[C:29]5[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=5)[N:23]([CH2:30][C:31]5[CH:36]=[CH:35][C:34]([Br:37])=[CH:33][CH:32]=5)[C:22]=4[CH:38]([CH3:40])[CH3:39])[O:18][C:17]3=[O:41])=[C:8]2[CH:42]([CH3:44])[CH3:43])=[CH:4][CH:3]=1.C(N1C2C(=CC=CC=2)C(C2(C3C4C(=CC=CC=4)N(CC)C=3C)C=COC2=O)=C1C)C>>[Br:1][C:2]1[CH:46]=[CH:45][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]([C:16]3[C:17](=[O:41])[O:18][CH:19]([C:21]4[C:29]5[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=5)[N:23]([CH2:30][C:31]5[CH:32]=[CH:33][C:34]([Br:37])=[CH:35][CH:36]=5)[C:22]=4[CH:38]([CH3:40])[CH3:39])[CH:20]=3)=[C:8]2[CH:42]([CH3:44])[CH3:43])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 204427343,5-bis[1-(4-bromobenzyl)-2-isopropyl-3-indolyl]-2(3H)-furanoneHCID 86735495bis(1-ethyl-2-methyl-3-indolyl)-2(3H)-furanone

Product 1

HCID 204427153,5-bis[1-(4-bromobenzyl)-2-isopropyl-3-indolyl]-2(5H)-furanone

Procedure

Substituting 3,5-bis[1-(4-bromobenzyl)-2-isopropyl-3-indolyl]-2(3H)-furanone for 3,5L -bis(1-ethyl-2-methyl-3-indolyl)-2(3H)-furanone in the procedure described in part B above in this example, there is obtained 3,5-bis[1-(4-bromobenzyl)-2-isopropyl-3-indolyl]-2(5H)-furanone (Formula IV: R=4-BrC6H4CH2 ; R1 =(CH3)2CH; Y=H).

Sources & evidence

ORD record
ord-599b8c57245f441fa00eedc63bd50f45
Source dataset
uspto-grants-1978_02
Patent number
US04075224

Reaction notes

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