Pyrazol-3-ylamine → HCID 178515100, compound

Participants

Reaction Steps

15.7 g. of 2-chloropyridine-3-carboxylic acid and 16.6 g. of 5-aminopyrazole are heated carefully to about 180°. At this point, the reaction starts and the temperature rises to about 230°-240°. The mixture is allowed to cool to room temperature and is then treated with methanol. The undissolved pyrazolo[1,5-a]pyrido[2,3-d]pyrimidin-9(4H)-one is filtered off and recrystallized from dimethylformamide, yield: 10.5 g. (56%); m.p. >300°.

Provenance & Evidence