2-Chloro-6-methylnicotinic acid → HCID 178422976, compound

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Reaction Steps

17.1 g. of 2-chloro-6-methylpyridine-3-carboxylic acid and 19.4 g. of 5-amino-3-methylpyrazole are heated together for 10 minutes at 180°-190°. The mixture is cooled to room temperature and treated with methanol. The crystalline 2,6-dimethylpyrazolo[1,5-a]pyrido[2,3-d]pyrimidin-9(4H)-one is filtered off and recrystallized from dimethylformamide, yield: 13.5 g. (64%); m.p. >300°.

Provenance & Evidence