Pyrazol-3-ylamine → HCID 178422975, compound

Participants

Reaction Steps

17.1 g. of 2-chloro-6-methylpyridine-3-carboxylic acid and 16.6 g. of 5-aminopyrazole are heated together at 180°-190° for 10 minutes. The mixture is cooled to room temperature and treated with methanol. The crystalline 6-methylpyrazolo[1,5-a]pyrido[2,3-d]pyrimidin-9(4H)-one is filtered off and recrystallized from dimethylformamide, yield: 11.3 g. (56%); m.p. >300°.

Provenance & Evidence