Acetic Acid → HCID 20366154, compound

Participants

Reaction Steps

6.3 Grams of 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylic acid was dissolved, at room temperature, in 100 ml. of glacial acetic acid. To that mixture was added 3.1 grams of m-chloroperbenzoic acid (85% by weight) and the resultant mixture was stirred at room temperature for a period of 11/2 hours, thereafter diluted with 500 ml. of water, cooled and filtered. The residual solid was washed successively with water chloroform, ether and warm methanol. Upon drying for 6 hours at 65° C. was afforded 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-N-oxidopiperidine-4-carboxylic acid, melting at about 186°-189° C., with decomposition.

Provenance & Evidence