Sodium Hydroxide → HCID 20366318, compound

Participants

Reaction Steps

Ethyl (6-chloro-4-oxo-4H-1-benzopyran-3-yl)aminooxoacetate (2.7g, 0.92 mole) was suspended in ethanol (100 ml) and water (100 ml). 0.1N sodium hydroxide solution was added dropwise, with occasional warming on a steam bath, until the reaction mixture remained slightly basic. The color of the mixture changed to orange on addition of the base and then back to white. The sodium hydroxide solution was added until a faint orange color persisted. The product was filtered off, triturated with 1N hydrochloric acid, washed with water and sucked dry on filter. Recrystallization from methanol gave white crystals (2,3g, 94%), m.p. 213°-215° C.

Provenance & Evidence