HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 616883Generated: October 25, 2026
Phosgene → 10-fluoro-5H-dibenz[b,f]azepine-5-carbonyl chloride
https://huagongshe.com/reaction/616883
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | 10-fluoro-5H-dibenz[b,f]azepine | HCID 20366408 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 10-fluoro-5H-dibenz[b,f]azepine-5-carbonyl chloride | HCID 20366410 | — |
Reaction Steps
A mixture of 2.3 g of 10-fluoro-5H-dibenz[b,f]azepine and 30 ml of toluene saturated with phosgene is stirred for 2 days at 25° C. Excess phosgene is then expelled with nitrogen and the reaction mixture is concentrated by rotary evaporation to yield crude 10-fluoro-5H-dibenz[b,f]azepine-5-carbonyl chloride as residue.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04076812 |
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| Source dataset | uspto-grants-1978_02 |
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| ORD ID | ord-84342a3214e94d54b38ef2410a598ec3 |
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| Source note | uspto-grants-1978_02 |
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