反应详情

To a solution of 4-hydroxy-4,5,6,7-tetrahydro-thieno[2,3-c]-pyridine (5.6 g; 36.2 mmoles) in benzene (40 cc), is added dropwise a mixture of phenyl isocyanate (4.3 g; 36.2 mmoles) in benzene (10 ml). After stirring during 2 hours at room temperature, the resulting precipitate is filtered off, washed with ether and dried in vacuo. On recrystallization from ethanol, the desired product is obtained in a yield of 65% (M.p. = 200° C).

1. filtrationthe resulting precipitate is filtered off
2. washwashed with ether
3. customdried in vacuo
4. customOn recrystallization from ethanol