Phenyl isocyanate → HCID 20366872, compound

HRID 616895Notes

Reaction equation

HRID 616895 reaction equation
[NH2:1][CH:2]1[CH2:11][CH:10]2[N:5]([CH2:6][CH2:7][C:8]3[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=32)[CH2:4][CH2:3]1.[C:16]1([N:22]=[C:23]=[O:24])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C1C=CC=CC=1>[CH2:11]1[CH:10]2[N:5]([CH2:6][CH2:7][C:8]3[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=32)[CH2:4][CH2:3][CH:2]1[NH:1][C:23]([NH:22][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:24]

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 129401711,3,4,6,7,11b-Hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Product 1

HCID 20366872HCID 20366872, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

To 2-amino-1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizine (0.436 g) stirred at room temperature in benzene (50 ml) was added phenyl isocyanate (0.290 g, 5% excess) in benzene (25 ml). After stirring for 18 hours, the title compound was filtered off as a white solid (0.621 g) which was converted in ethanolic hydrogen chloride to the hydrochloride (0.654 g), m.p. 210.1° C. C20H23N3O.HCl.H2O requires C, 63.90; H, 6.97; N, 11.18% Found: C, 63.72; H, 6.87; N, 11.10%.

Workup

  1. filtrationthe title compound was filtered off as a white solid (0.621 g) which

Sources & evidence

ORD record
ord-4bee26ee24b4462498d1c5ad7f60e1e6
Source dataset
uspto-grants-1978_02
Patent number
US04076820

Reaction notes

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