Benzoyl isocyanate → HCID 20366863, compound

HRID 616897Notes

Reaction equation

HRID 616897 reaction equation
[NH2:1][CH:2]1[CH2:11][CH:10]2[N:5]([CH2:6][CH2:7][C:8]3[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=32)[CH2:4][CH2:3]1.[C:16]([N:24]=[C:25]=[O:26])(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C1C=CC=CC=1>[CH2:11]1[CH:10]2[N:5]([CH2:6][CH2:7][C:8]3[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=32)[CH2:4][CH2:3][CH:2]1[NH:1][C:25]([NH:24][C:16](=[O:23])[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)=[O:26]

Participants

4

Reactant 2

HCID 78210Benzoyl isocyanateHCID 129401711,3,4,6,7,11b-Hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine

Product 1

HCID 20366863HCID 20366863, compoundYield 72.4%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

2-Amino-1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizine (0.260 g) and benzoyl isocyanate (0.213 g, 5% excess) were condensed together in benzene (50 ml) in a manner analogous to that of Example 1 to give the title compound (0.325 g). Crystallization from EtOH/HCl afforded the hydrochloride (0.343 g). m.p. 171.0° C. C21H23N3O2.HCl.2H2O requires C, 59.78; H, 6.69; N, 9.96%, Found: C, 60.06; H, 6.50; N 9.89%.

Sources & evidence

ORD record
ord-32b78603c1a04b288a9b215fa517ddf3
Source dataset
uspto-grants-1978_02
Patent number
US04076820

Reaction notes

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