1-(1,3,4,6,7,11b-Hexahydro-2H-benzo[a]quinolizin-2-yl)-3-benzoylurea hydrochloride → 1,3,4,6,7,11b-Hexahydro-2H-benzoquinolizin-2-ylurea

HRID 616900Notes

Reaction equation

HRID 616900 reaction equation
Cl.[CH2:2]1[CH:11]2[N:6]([CH2:7][CH2:8][C:9]3[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=32)[CH2:5][CH2:4][CH:3]1[NH:16][C:17]([NH:19]C(=O)C1C=CC=CC=1)=[O:18]>[OH-].[Na+]>[CH2:2]1[CH:11]2[N:6]([CH2:7][CH2:8][C:9]3[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=32)[CH2:5][CH2:4][CH:3]1[NH:16][C:17]([NH2:19])=[O:18]

Participants

3

Reactant 1

HCID 203668731-(1,3,4,6,7,11b-Hexahydro-2H-benzo[a]quinolizin-2-yl)-3-benzoylurea hydrochloride

Product 1

HCID 203668691,3,4,6,7,11b-Hexahydro-2H-benzoquinolizin-2-ylureaYield 73.8%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

1-(1,3,4,6,7,11b-Hexahydro-2H-benzo[a]quinolizin-2-yl)-3-benzoylurea hydrochloride (0.98 g) was refluxed in 2N sodium hydroxide solution (50 ml) for 4 hours. The solution was filtered and the residue washed with water, then ethanol, and finally ether before drying to give the title compound (0.46 g) melting point 235° C. C14H19N3O requires: C, 68.54%; H, 7.81%; N, 17.13%. Found: C, 68.53%; H, 7.79%; N, 17.33%.

Workup

  1. filtrationThe solution was filtered
  2. washthe residue washed with water
  3. dry with materialethanol, and finally ether before drying

Sources & evidence

ORD record
ord-40d2e6a16a0c4c6a961e4fef1a460dda
Source dataset
uspto-grants-1978_02
Patent number
US04076820

Reaction notes

Loading…