反应详情

(Method 3) To nitrobenzene (5 ml) and aluminum chloride (400 mg, 3 mmol), 4-methoxybenzoyl chloride (400 mg, 2.3 mmol) was added. After stirring for 30 min at room temperature, 2-(1-hydroxy-1-methyl-ethyl)-1H-indole-6-carbonitrile (Compound AA6, 200 mg, 1 mmol) was added followed by stirring at room temperature for 3 hr. Water was added to the reaction solution, which was then extracted with ethyl acetate. The organic layer was dried over sodium sulfate. The drying agent was removed by filtration and the residues obtained after concentration under reduced pressure were purified by silica gel column chromatography (hexane/ethyl acetate) to obtain the title compound (127 mg, 40%).

1. stirringby stirring at room temperature for 3 hr
2. extractionwas then extracted with ethyl acetate
3. dry with materialThe organic layer was dried over sodium sulfate
4. customThe drying agent was removed by filtration
5. customthe residues obtained
6. concentrationafter concentration under reduced pressure
7. customwere purified by silica gel column chromatography (hexane/ethyl acetate)