Pirquinozol → HCID 135737583, compound

HRID 616938Notes

Reaction equation

HRID 616938 reaction equation
[OH:1][CH2:2][C:3]1[CH:15]=[C:14]2[N:5]([C:6](=[O:16])[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=32)[N:4]=1>C(O)(=O)CC>[C:2]([O:1][CH2:2][C:3]1[CH:15]=[C:14]2[N:5]([C:6](=[O:16])[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=32)[N:4]=1)(=[O:1])[CH2:3][CH3:15]

Participants

3

Reactant 1

HCID 135449340Pirquinozol

Product 1

HCID 135737583HCID 135737583, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 1032Propionic AcidSolvent

Procedure

2-(Hydroxymethyl)pyrazolo[1,5-c]quinazolin-5(6H)-one 83.0 g, 0.0139 mole) is suspended in 250 ml of propionic acid and the mixture refluxed overnight under nitrogen. The resultant solution is stripped to a solid and recrystallized from absolute ethanol to give 2.6 g(69% yield) of analytically pure title compound, m.p. 184°-186°.

Workup

  1. temperaturethe mixture refluxed overnight under nitrogen
  2. customrecrystallized from absolute ethanol

Sources & evidence

ORD record
ord-45c7af50d18b44c8beee26f818a12de3
Source dataset
uspto-grants-1978_02
Patent number
US04076818

Reaction notes

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