Acetic Anhydride → HCID 135737589, compound

HRID 616946Notes

Reaction equation

HRID 616946 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[NH:8][C:7](=[O:12])[N:6]3[N:13]=[C:14]([CH2:16][OH:17])[CH:15]=[C:5]3[C:4]=2[CH:3]=1.[C:18](OC(=O)C)(=[O:20])[CH3:19]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[NH:8][C:7](=[O:12])[N:6]3[N:13]=[C:14]([CH2:16][O:17][C:18](=[O:20])[CH3:19])[CH:15]=[C:5]3[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 135737572HCID 135737572, compound

Product 1

HCID 135737589HCID 135737589, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2.50 g (0.01 mole) of 9-chloro-2-(hydroxymethyl)pyrazolo-[1,5-c]quinazolin-5(6H)-one and 1.02 g of acetic anhydride in 50 ml pyridine are stirred for 12 hours then refluxed for 30 minutes. The reaction is evaporated; the residue is taken up in chloroform, washed with dilute aqueous sodium bicarbonate, with water and dried. The solvent is evaporated to give the title compound.

Workup

  1. temperaturethen refluxed for 30 minutes
  2. customThe reaction is evaporated
  3. washwashed with dilute aqueous sodium bicarbonate, with water
  4. customdried
  5. customThe solvent is evaporated

Sources & evidence

ORD record
ord-e0119038e8894a0a9928dbaa02314174
Source dataset
uspto-grants-1978_02
Patent number
US04076818

Reaction notes

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