Cyclohexylamine → HCID 20367028, compound

HRID 616970Notes

Reaction equation

[C:1]([CH2:4][C:5]1[CH:19]=[CH:18][C:8]([CH:9]([CH2:14][CH:15]([CH3:17])[CH3:16])[CH2:10][C:11]([OH:13])=O)=[CH:7][CH:6]=1)([OH:3])=[O:2].C1(N)CCCCC1>>[CH2:14]([CH:9]1[C:8]2[C:18](=[CH:19][C:5]([CH2:4][C:1]([OH:3])=[O:2])=[CH:6][CH:7]=2)[C:11](=[O:13])[CH2:10]1)[CH:15]([CH3:17])[CH3:16]

Participants

Reactant 2

HCID 7965Cyclohexylamine

HCID 20367015HCID 20367015, compound

Product 1

HCID 20367028HCID 20367028, compound

Procedure

4-carboxymethyl-β-isobutyl-dihydrocinnamic acid is cyclized in a manner analogous to that described in Example 1. The cyclohexylamine salt of the title compound has a M.P. of 140°-142° (from methanol/ether).

Sources & evidence

ORD record: ord-6f7a8e93ee84496d8011c954376a1d44
Source dataset: uspto-grants-1978_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04076838

Reaction notes

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