Hydrochloric Acid → Propionic Acid

Participants

Reaction Steps

To bis(1-hydroxycyclopropyl)-amine (50 mg) [W. J. M. van Tilborg, Thesis, Amsterdam 1971] in D2O is added a small excess of conc. HCl. The NMR-spectrum shows a singlet for bis(1-hydroxycyclopropyl)-ammonium chloride (δD 2O = 1.25 (s, 4H)). The sample is heated at 80° for 4 hr yielding 1-hydroxycyclopropylammonium chloride (δD 2O = 1.17 (s, 4H)) and propionic acid. (The decomposition is much faster at higher HCl concentrations). Evaporation gives, as an oil, 1-hydroxycyclopropylammonium chloride.

Provenance & Evidence