Potassium Carbonate → HCID 20366938, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 13.5 g of 3,3-bis(p-fluorophenyl)cyclopentyl tosylate (nD20 1.5691), 7.5 g of 1-(4-piperidyl)-5-chloro-2-benzimidazolinone hydrochloride, 8.6 g of potassium carbonate and 70 ml of dimethylformamide is stirred at 70° C for 52 hours. The reaction mixture is poured into ice water, and the aqueous layer is removed by decantation. The precipitated semi-solid is dissolved in chloroform. The solution is washed with water and dried over sodium sulfate, and the solvent is removed. The crude crystals are recrystallized from a mixture of chloroform and ethanol (20:1) to give 1-[1-(3,3-bis(p-fluorophenyl)cyclopentyl)-4-piperidyl]-5-chloro-2-benzimidazolinone as white crystals, melting at 131°-134° C.

Provenance & Evidence