HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → HCID 13364149, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(4-Bromophenyl)-1,3,8-triazaspiro[4.5]decan-4-one | HCID 13364143 | — |
| Reactant | 2~4~-Chloro-1~4~,3~4~-difluoro-2~3~,2~4~-dihydro-2~2~H-1~1~,2~1~:2~1~,3~1~-terphenyl | HCID 13364147 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 13364149 | HCID 13364149 | — |
Reaction Steps
A mixture of 3.7 g of 4,4-bis(p-fluorophenyl)-1-chloro-2-cyclohexene, 3.1 g of 1-(p-bromophenyl)-1,3,8-triazaspiro[4.5]decan-4-one (m.p. 204°-207° C), 1.7 g of potassium carbonate, 2 g of potassium iodide and 25 ml of dimethylformamide is stirred at 65°-75° C for 3.5 hours. The reaction mixture is then poured into water. The precipitated powder is collected by filtration and dissolved in methanol. The solution is concentrated to some degree, and acetone is added thereto, and the whole mixture is cooled. The precipitated crystals are collected by filtration and purified in the same manner to give 8-[4,4-bis(p-fluorophenyl)-2-cyclohexenyl]-1-(p-bromophenyl)-1,3,8-triazaspiro[4.5]decan-4-one as white crystals, melting at 219°-221° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04076821 |
| Source dataset | uspto-grants-1978_02 |
| ORD ID | ord-e386aa055bd549aeb8f2e1ddcead6155 |
| Source note | uspto-grants-1978_02 |