Ethanol → HCID 178467475, compound

Participants

Reaction Steps

To a solution of 4.6 g of sodium in 150 ml of absolute ethanol there is added dropwise at 60° C 31.4 g of 2-ethyl-2-cyanohydrazinecarboxylic acid ethyl ester. The solution is subsequently refluxed for 4 hours. From the cooled solution there precipitates, after the addition of 12 g of glacial acetic acid, sodium acetate, which is separated by filtration. The filtrate is concentrated in vacuo to dryness, and the residue is extracted with 200 ml of chloroform. The extract is again concentrated to dryness and the residue is recrystallised from cyclohexane. There is obtained 18.8 g (60% of theory) of 1-ethyl-5-ethoxy-3-hydroxy-1,2,4-triazole, m.p. 64° to 67° C.

Provenance & Evidence