Ethanethiol → HCID 178477362, compound

Participants

Reaction Steps

To an ethanolic solution of sodium ethylate produced from 4.6 g of sodium and 100 ml of absolute ethanol there is firstly added dropwise 14.9 g of ethyl mercaptan and subsequently 31.4 g of 2-ethyl-2-cyanohydrazinecarboxylic acid ethyl ester is added dropwise. There is formed a crystalline precipitate, which is refluxed for 3 hours. The cooled suspension is freed, after the addition of 12 g of glacial acetic acid, by filtration from the precipitated sodium acetate, and the filtrate is concentrated in vacuo to dryness. 200 ml of chloroform is added to the residue and filtration is performed. The filtrate is again concentrated to dryness. The residue is recrystallised with cyclohexane. There is obtained 26 g (75% of theory) of 1-ethyl-5-ethylthio-3-hydroxy-1,2,4-triazole, m.p. 65°-68° C.

Provenance & Evidence