HRID617087

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(O)CNC(c1ccccc1)(c1ccccc1)c1ccccc1

HCID248898

N-Tritylglycine

C21H19NO2

结构：Cl.Cn1c(CN)c(-c2ccccc2Cl)c2cc(Cl)ccc21

HCID70582520

未命名化合物

PRODUCTS

生成物

结构：Cn1c(CNC(=O)CNC(c2ccccc2)(c2ccccc2)c2ccccc2)c(-c2ccccc2Cl)c2cc(Cl)ccc21

HCID70582786

未命名化合物

PROCEDURE

实验过程

Using 1-methyl-2-aminomethyl-3-o-chlorophenyl-5-chloroindole hydrochloride and N-tritylglycine, the reaction is effected as in Example 12 (1), whereby 1-methyl-2-(N-trityl-glycylaminomethyl)-3-o-chlorophenyl-5-chloroindole is obtained as crystals melting at 198° to 200° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-893da600a22e49aebe41387a9ab63a14
来源数据集: uspto-grants-1978_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04076704
来源说明: uspto-grants-1978_02

反应 SMILES

Cl.[CH3:2][N:3]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[C:5]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:19])=[C:4]1[CH2:20][NH2:21].[C:22]([NH:41][CH2:42][C:43](O)=[O:44])([C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH3:2][N:3]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[C:5]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:19])=[C:4]1[CH2:20][NH:21][C:43](=[O:44])[CH2:42][NH:41][C:22]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)([C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1)[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1