Ethyl 2-chloroethylcarbamate → [2-(3-Cyano-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yloxy)-ethyl]-carbamic acid ethyl ester

HRID 61710Notes

Reaction equation

HRID 61710 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[C:17](=[O:18])[C:16]3[C:15]4[C:10](=[CH:11][C:12]([C:19]#[N:20])=[CH:13][CH:14]=4)[NH:9][C:8]=3[C:7]([CH3:22])([CH3:21])[C:6]=2[CH:23]=1.[CH2:24]([O:26][C:27](=[O:32])[NH:28][CH2:29][CH2:30]Cl)[CH3:25]>>[CH2:24]([O:26][C:27](=[O:32])[NH:28][CH2:29][CH2:30][O:1][C:2]1[CH:3]=[CH:4][C:5]2[C:17](=[O:18])[C:16]3[C:15]4[C:10](=[CH:11][C:12]([C:19]#[N:20])=[CH:13][CH:14]=4)[NH:9][C:8]=3[C:7]([CH3:21])([CH3:22])[C:6]=2[CH:23]=1)[CH3:25]

Participants

3

Reactant 2

HCID 80621Ethyl 2-chloroethylcarbamateHCID 668338618-Hydroxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

Product 1

HCID 67150071[2-(3-Cyano-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yloxy)-ethyl]-carbamic acid ethyl ester

Procedure

Under the same conditions as the method for synthesizing Compound A7-17, the title compound was prepared from Compound A6 and ethyl-2-chloroethylcarbamate.

Workup

  1. customUnder the same conditions as the method for synthesizing Compound A7-17

Sources & evidence

ORD record
ord-3a4c6b8ecdf849daa488f6ef8db126ce
Source dataset
uspto-grants-2016_09
Patent number
US09440922B2

Reaction notes

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