反应详情

To a solution of 20.05 g (0.0736 mol) of 2-amino-N-(4-methoxy-phenyl)-3-methoxy-benzamide in 400 mL of ethanol was added 13.6 g (0.0736 mol) of p-(2-chloro-ethoxy)-benzaldehyde (Frinton Labs), and 10 mL of acetic acid. The reaction mixture was stirred and heated to a mild reflux overnight. After cooling to room temperature, the solvent was evaporated in a rotary evaporator. The residue was dissolved in 300 mL of ethyl acetate and washed with water (4×100 mL). The organic phase was removed, dried over magnesium sulfate, filtered and evaporated to dryness in a rotary evaporator. The residual oil was placed under the vacuum pump, which yielded 26.0 g (mp 122-124° C.) of product.

1. temperatureheated to
2. temperaturea mild reflux overnight
3. customthe solvent was evaporated in a rotary evaporator
4. dissolutionThe residue was dissolved in 300 mL of ethyl acetate
5. washwashed with water (4×100 mL)
6. customThe organic phase was removed
7. dry with materialdried over magnesium sulfate
8. filtrationfiltered
9. customevaporated to dryness in a rotary evaporator