HCID 57207766, compound → HCID 54408787, compound

HRID 617135Notes

Reaction equation

HRID 617135 reaction equation
C(OC([NH:8][C@H:9]([C:13]([NH:15][CH:16]([CH2:32][C:33]1[CH:38]=[CH:37][C:36]([O:39][CH2:40][CH2:41][N:42]2[CH2:47][CH2:46][O:45][CH2:44][CH2:43]2)=[CH:35][CH:34]=1)[CH:17]([OH:31])[C:18]([F:30])([F:29])[C:19]([NH:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:20])=[O:14])[CH:10]([CH3:12])[CH3:11])=O)(C)(C)C>C(O)=O>[NH2:8][C@H:9]([C:13]([NH:15][CH:16]([CH2:32][C:33]1[CH:38]=[CH:37][C:36]([O:39][CH2:40][CH2:41][N:42]2[CH2:43][CH2:44][O:45][CH2:46][CH2:47]2)=[CH:35][CH:34]=1)[CH:17]([OH:31])[C:18]([F:30])([F:29])[C:19]([NH:21][CH2:22][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)=[O:20])=[O:14])[CH:10]([CH3:12])[CH3:11]

Participants

3

Reactant 1

HCID 57207766HCID 57207766, compound

Product 1

HCID 54408787HCID 54408787, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A solution of 4(N-tert-butoxycarbonyl-L-valyl)amino-2,2-difluoro-3-hydroxy-5[4(2-{N-Morpholinyl}Ethyloxy)Phenyl]N-benzyl pentanamide (0.19 g, 0.28 mmol) in formic acid (15 ml) was stirred at room temperature for 4 hours. After evaporation of the solvent in vacuo, the residue was diluted with ethyl acetate (50 ml) and washed three times with a saturated solution of sodium carbonate (3×10 ml) and brine (10 ml). The organic layer was dried over magnesium sulphate.

Workup

  1. customAfter evaporation of the solvent in vacuo
  2. additionthe residue was diluted with ethyl acetate (50 ml)
  3. washwashed three times with a saturated solution of sodium carbonate (3×10 ml) and brine (10 ml)
  4. dry with materialThe organic layer was dried over magnesium sulphate

Sources & evidence

ORD record
ord-728925f7250e454eb3962dcbf359b4ca
Source dataset
uspto-grants-1999_09
Patent number
US05948778

Reaction notes

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