HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → HCID 21851267, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 3-[1-(6-Ethoxy-7-hydroxy-2-morpholino-4-quinazolinyl)-4-piperidinyl]-1,2,3,4-tetrahydro-1,6-dimethyl-2,4-dioxoquinazoline | HCID 135822834 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 21851267 | HCID 21851267 | 53% |
Reaction Steps
In 3 ml of pyridine was dissolved 360 mg (0.66 mmol) of Compound 47 obtained in Example 47, 0.12 ml (1.32 mmol) of acetic anhydride was added, and the mixture was stirred at room temperature for 4 hours. The solvent was removed at reduced pressure and water was added to the residue, the resulting precipitate was collected by filtration, washed with water, dried at heating and recrystallized from ethanol to give 205 mg (yield: 53%) of Compound 52 as white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05948784 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-cb996b9e29db4200b35cf15db1512dab |
| Source note | uspto-grants-1999_09 |