HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 21851309, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | N,N-Dimethylaminoethyl chloride hydrochloride | HCID 11636816 | — |
| Reactant | 3-[1-(6-Ethoxy-7-hydroxy-2-morpholino-4-quinazolinyl)-4-piperidinyl]-1,2,3,4-tetrahydro-1,6-dimethyl-2,4-dioxoquinazoline | HCID 135822834 | — |
| Product | HCID 21851309 | HCID 21851309 | 31% |
Reaction Steps
The same procedure as in Example 48 was repeated, using 360 mg (0.66 mmol) of Compound 47 obtained in Example 47 and 2 equivalents of sodium hydride (60% in oil), except that 2-dimethylaminoethyl chloride hydrochloride was used in place of methyl iodide and reaction temperature was 60° C. in place of room temperature, to give 127 mg (yield: 31%) of Compound 53 as white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05948784 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-cf3a0973e45c4a75a35989e6b88a6a87 |
| Source note | uspto-grants-1999_09 |