Ethyl bromoacetate → HCID 21851308, compound

HRID 617168Notes

Reaction equation

[CH2:1]([O:3][C:4]1[CH:13]=[C:12]2[C:7]([C:8]([N:20]3[CH2:25][CH2:24][CH:23]([N:26]4[C:35](=[O:36])[C:34]5[C:29](=[CH:30][CH:31]=[C:32]([CH3:37])[CH:33]=5)[N:28]([CH3:38])[C:27]4=[O:39])[CH2:22][CH2:21]3)=[N:9][C:10]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)=[N:11]2)=[CH:6][C:5]=1[OH:40])[CH3:2].Br[CH2:42][C:43]([O:45][CH2:46][CH3:47])=[O:44]>>[CH2:1]([O:3][C:4]1[CH:13]=[C:12]2[C:7]([C:8]([N:20]3[CH2:25][CH2:24][CH:23]([N:26]4[C:35](=[O:36])[C:34]5[C:29](=[CH:30][CH:31]=[C:32]([CH3:37])[CH:33]=5)[N:28]([CH3:38])[C:27]4=[O:39])[CH2:22][CH2:21]3)=[N:9][C:10]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)=[N:11]2)=[CH:6][C:5]=1[O:40][CH2:42][C:43]([O:45][CH2:46][CH3:47])=[O:44])[CH3:2]

Participants

Reactant 2

HCID 7748Ethyl bromoacetate

HCID 21851252HCID 21851252, compound

Product 1

HCID 21851308HCID 21851308, compoundYield 64%

Procedure

The same procedure as in Example 48 was repeated, except that 290 mg (0.53 mmol) of Compound 59 obtained in Example 59 was used in place of Compound 47 obtained in Example 47, and ethyl bromoacetate was used in place of methyl iodide, to give 216 mg (yield: 64%) of Compound 60 as white crystals.

Sources & evidence

ORD record: ord-8241e7b8fccd4cde907d577c9f829928
Source dataset: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05948784

Reaction notes

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