Hydrochloric Acid → HCID 21851184, compound

Participants

Reaction Steps

A solution of hydrogen chloride in ethanol (27%, 1.3 g) was added dropwise at room temperature to a solution of ethyl 6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2-[(1-methylimidazol-2-yl)thiomethyl]quinoline-3-carboxylate (4.9 g) in ethanol (100 ml). About two thirds of the solvent was distilled off under reduced pressure. Ethyl ether was added to the residue, and the deposited crystals were separated by filtration. The separated crystals were recrystallized from isopropanol to obtain ethyl 6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2-[(1-methylimidazol-2-yl)thiomethyl]quinoline-3-carboxylate hydrochloride monohydrate (3.0 g, 55%).

Provenance & Evidence