Sodium Hydroxide → HCID 21851157, compound

Participants

Reaction Steps

A mixture of ethyl 6,7-dimethoxy-4-(3,4-dimethoxy- phenyl)-2-[(1-methylimidazol-2-yl)thiomethyl]quinoline-3-carboxylate (0.6 g), 2N NaOH (1.7 ml) and ethanol (12 ml) was refluxed for 6 hours. The reaction mixture was concentrated in vacuo. The residue was diluted with H2O, washed with ethyl acetate, acidified with 2N HCl and extracted with ethyl acetate. The extract was washed with H2O, dried over MgSO4, and concentrated in vacuo to give crystals. Recrystallization from ethanol-ethyl ether gave 6,7-dimethoxy-4-(3,4-dimethoxyphenyl)-2-[(1-methylimidazol-2-yl)thiomethyl]quinoline-3-carboxylic acid (0.3 g, 53%) as colorless prisms, mp 213-214° C.

Provenance & Evidence