4,7-Dichloroquinoline → HCID 178521589, compound

Participants

Reaction Steps

414.2 g of 4,7-dichloroquinoline, 380 g of trans-4-amino-cyclohexanol hydrochloride and 255 9 of triethylamine were heated to reflux overnight in 1.05 l of 1-methyl-2-pyrrolidone under an argon atmosphere. After cooling the reaction mixture 3.8 l of water and 380 ml of 28% sodium hydroxide solution were added thereto while stirring and cooling. The separated reaction product was filtered off under suction, washed with water until the wash water was neutral and dried at 100° C./12 mbar. Yield 491 g (84.9%) of trans-N-(7-chloro-quinolin-4-yl)-4-aminocyclohexanol.

Provenance & Evidence