HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → 7-Chloro-5-nitro-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone | HCID 6775 | — |
| Reactant | 7-Chloro-2,3-dihydro-5-nitro-1H-indole | HCID 15541433 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 7-Chloro-5-nitro-1H-indole | HCID 15453464 | 79% |
Reaction Steps
To a solution of 7-chloro-5-nitroindoline (0.23 g, 1.2 mmol) in 20 mL of acetone was added 2,3-dichloro-5,6-dicyano-1,4-benzoquinone until color of the solution turns to dark green. Reaction mixture was concentrated in vacuo providing a dark residue which was subjected to column chromatography (CHCl3, neat) to yield 0.18 g (0.94 mmol, 79%) of the indole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05948804 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-b8b4e89bdf8d4693bcebf7a07bcd8096 |
| Source note | uspto-grants-1999_09 |