HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine → 5-amino-1H-indole-7-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 7-Cyano-5-nitroindole | HCID 15453467 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-amino-1H-indole-7-carbonitrile | HCID 15453468 | 100.9% |
Reaction Steps
A solution of 7-cyano-5-nitroindole (1.5 g, 8.2 mmol), hydrazine (1.0 mL, 31.2 mmol) and 10% Pd/C (20 mg) in 30 mL of MeOH was stirred a: reflux for 2 h. The reaction mixture was filtered and concentrated in vacuo to provide 1.3 g (>95%) of the amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05948804 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-bff7b0f488064709903c2acea0323cae |
| Source note | uspto-grants-1999_09 |