Hydrochloric Acid → 5-chloro-3-((1-methyl-(R)-pyrrolidinyl)methoxy)pyridine dihydrochloride

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Reaction Steps

The compound of step 34a was treated with HCl as described in Example 1b and the title compound was isolated as a white powder. MS and 1H NMR (D2O, 300 Hz) are similar to 16b. Anal. Calc for C11H15N2OCl.2.00 HCl: C, 44.10; H, 5.20; N, 9.35; Found C, 43.98; H, 5.81; N, 9.33. [α]25D =+ 5.59° (c=1, MeOH).

Provenance & Evidence