HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-(-)-N-Boc-prolinol → (R)-2-Methyl-3-(2-pyrrolidinylmethoxy)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-(-)-N-Boc-prolinol | HCID 643448 | — |
| Reactant | N-(tert-Butoxycarbonyl)-D-prolinol | HCID 688279 | — |
| Reactant | 5-chloro-3-((1-t-butoxycarbonyl-2-(S)-pyrrolidinyl)methoxy)pyridine | HCID 54299383 | — |
| Product | (R)-2-Methyl-3-(2-pyrrolidinylmethoxy)pyridine | HCID 127922 | — |
Reaction Steps
Replacing (S)-1-t-butoxycarbonyl-2-pyrrolidinemethanol of Example 15 with (R)-1-t-butoxycarbonyl-2-pyrrolidinemethanol (Aldrich Chemical Co.), and following the procedure of steps 15a and 15b, the title compound was prepared. The MS and 1H NMR spectra were similar to compound 15a.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05948793 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-80b6a394a4c94df6ab5e52b4ae96a0fd |
| Source note | uspto-grants-1999_09 |