3,5-Dibromopyridine 1-oxide → 3-Bromo-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-pyridine 1-oxide

HRID 617362Notes

Reaction equation

HRID 617362 reaction equation
Br[C:2]1[CH:3]=[N+:4]([O-:9])[CH:5]=[C:6]([Br:8])[CH:7]=1.[CH3:10][N:11]1[CH2:15][CH2:14][CH2:13][C@H:12]1[CH2:16][OH:17]>>[CH3:10][N:11]1[CH2:15][CH2:14][CH2:13][C@H:12]1[CH2:16][O:17][C:2]1[CH:3]=[N+:4]([O-:9])[CH:5]=[C:6]([Br:8])[CH:7]=1

Participants

3

Reactant 2

HCID 6200033,5-Dibromopyridine 1-oxideHCID 643492(2S)-1-Methyl-2-pyrrolidinemethanol

Product 1

HCID 213096723-Bromo-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-pyridine 1-oxide

Procedure

A sample of 3,5-dibromopyridine-N-oxide (prepared according to the method of Y. Tamura et al., Heterocycles, 15:871-874 (1981)) is reacted with (S)-(-)-1-methyl-2-pyrrolidinemethanol according to the procedure of Example 3a, and the product is purified by chromatography on silica gel.

Workup

  1. customthe product is purified by chromatography on silica gel

Sources & evidence

ORD record
ord-aff1e832d66e4ff49676770e755fcc3b
Source dataset
uspto-grants-1999_09
Patent number
US05948793

Reaction notes

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