HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-5methoxy-pyridine-N-oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 3-Bromo-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-pyridine 1-oxide | HCID 21309672 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-5methoxy-pyridine-N-oxide | HCID 21309673 | — |
Reaction Steps
A sample of 3-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-5bromo-pyridine-N-oxide, from Example 98a above, is reacted with sodium cyanide in DMF and water according to standard procedures. The solvents are removed, and the product is extracted, then purified by chromatography on silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05948793 |
| Source dataset | uspto-grants-1999_09 |
| ORD ID | ord-89998bd42b784f44b6e4bbf02bf3ce1e |
| Source note | uspto-grants-1999_09 |