反应详情

To a solution of 61 mg of (2R,5R)-2-(t-butyl)-5-[(1R)-3-oxocyclopentyl]-5-phenyl-1,3-dioxolan-4-one in 3 ml of methanol, 1 ml of 1N aqueous sodium hydroxide solution was added, followed by stirring for 3 hours at room temperature. Distilling the methanol off under reduced pressure, the residue was diluted with water and washed with diethyl ether. The aqueous layer was made acidic with 1N hydrochloric acid and extracted with diethyl ether. The organic layer was dried over anhydrous magnesium sulfate to provide 48 mg of the title compound.

1. distillationDistilling the methanol off under reduced pressure
2. additionthe residue was diluted with water
3. washwashed with diethyl ether
4. extractionextracted with diethyl ether
5. dry with materialThe organic layer was dried over anhydrous magnesium sulfate